Born in Savona, Tiziana Ghiglioni starts her musical training in the seventies, attending workshops held by pianist and composer Giorgio Gaslini, and studying vocal technique with soprano Gabriella Ravazzi.
Among her early professional experiences we mention the theatrical tour with the show "Shakespeare/Ellington", with Giorgio Albertazzi and Gaslini himself.

During the early eighties she starts her career as a jazz singer and band leader , immediately capturing the attention of both audiences and critics, also helped by journalist and jazz historian Arrigo Polillo's reviews, which favourably commented her former live performances and first LP ("Lonely Woman", 1981), recorded with some young emerging musicians like Piero Leveratto and Luigi Bonafede.

Thanks to the great success achieved with the first LP, on the second one ("Sounds of Love, 1983") Ghiglioni sings with worldwide-famous musicians, such as Kenny Drew on piano and Niels-Henning Ørsted Pedersen on double-bass.
During the following years she consolidates her outstanding role in the italian jazz scene, working with many famous italian jazz musicians (Luca Flores, Enrico Pieranunzi, Paolo Fresu, Franco D'Andrea, Gianluigi Trovesi and Enrico Rava, to name a few), and also with international jazz stars such as Chet Baker, Steve Lacy, Mal Waldron, Paul Bley and Lee Konitz.

Though she's mostly appreciated for her renditions of tunes from the standard jazz repertoire, Ghiglioni particularly loves free jazz and stylistic contaminations. She once stated that her love for jazz music comes from listening to saxophonist Archie Shepp, an ensign of free jazz. This interest in the avant-garde is well represented on the LP "SONB", recorded in 1992, which was rated second best album on magazine Musica Jazz's poll, and rewarded Ghiglioni with the nickname of First Lady of italian Jazz.
When talking about experimental projects, it's impossible not to mention the LP "Rotella Variations" (with violinist Emanuele Parrini) , an ambitious attempt to transpose into music the suggestive world of contemporary visual artist Mimmo Rotella.
In 2009 Tiziana Ghiglioni was President of the Artistic Committee of the Italian Jazz Awards-Luca Flores.
Right now she teaches jazz singing in the Conservatory of Milan and Ferrara.